CTGS: Cancer Target Gene Screening

METABRIC

Breast cancer dataset (Nature 2012 & Nat Commun 2016, 1980 patients)

Target gene screening by amplification

Min amp. freq.

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Or genes

Insert MSigDB gene set name directly or select one in following H category.

DB	Category	Name	Description	Number of genes
MSigDB	H1	HALLMARK_ANDROGEN_RESPONSE	Genes defining response to androgens	100
MSigDB	H1	HALLMARK_ANGIOGENESIS	Genes up-regulated during formation of blood vessels (angiogenesis)	35
MSigDB	H1	HALLMARK_APOPTOSIS	Genes mediating programmed cell death (apoptosis) by activation of caspases	160
MSigDB	H1	HALLMARK_DNA_REPAIR	Genes involved in DNA repair	149
MSigDB	H1	HALLMARK_E2F_TARGETS	Genes encoding cell cycle related targets of E2F transcription factors	199
MSigDB	H1	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis	199
MSigDB	H1	HALLMARK_ESTROGEN_RESPONSE_EARLY	Genes defining early response to estrogen	199
MSigDB	H1	HALLMARK_ESTROGEN_RESPONSE_LATE	Genes defining late response to estrogen	199
MSigDB	H1	HALLMARK_G2M_CHECKPOINT	Genes involved in the G2/M checkpoint, as in progression through the cell division	199
MSigDB	H1	HALLMARK_HEDGEHOG_SIGNALING	Genes up-regulated by activation of hedgehog signaling	35
MSigDB	H1	HALLMARK_HYPOXIA	Genes up-regulated in response to low oxygen levels (hypoxia)	199
MSigDB	H1	HALLMARK_IL2_STAT5_SIGNALING	Genes up-regulated by STAT5 in response to IL2 stimulation	199
MSigDB	H1	HALLMARK_IL6_JAK_STAT3_SIGNALING	Genes up-regulated by IL6 [GeneID=3569] via STAT3 [GeneID=6774], e.g., during acute phase response	86
MSigDB	H1	HALLMARK_INFLAMMATORY_RESPONSE	Genes defining inflammatory response	199
MSigDB	H1	HALLMARK_KRAS_SIGNALING_DN	Genes down-regulated by KRAS activation	199
MSigDB	H1	HALLMARK_KRAS_SIGNALING_UP	Genes up-regulated by KRAS activation	199
MSigDB	H1	HALLMARK_MYC_TARGETS_V1	A subgroup of genes regulated by MYC - version 1 (v1)	199
MSigDB	H1	HALLMARK_MYC_TARGETS_V2	A subgroup of genes regulated by MYC - version 2 (v2)	57
MSigDB	H1	HALLMARK_MYOGENESIS	Genes involved in development of skeletal muscle (myogenesis)	199
MSigDB	H1	HALLMARK_NOTCH_SIGNALING	Genes up-regulated by activation of Notch signaling	31
MSigDB	H1	HALLMARK_P53_PATHWAY	Genes involved in p53 pathways and networks	199
MSigDB	H1	HALLMARK_PI3K_AKT_MTOR_SIGNALING	Genes up-regulated by activation of the PI3K/AKT/mTOR pathway	104
MSigDB	H1	HALLMARK_TGF_BETA_SIGNALING	Genes up-regulated in response to TGFB1 [GeneID=7040]	53
MSigDB	H1	HALLMARK_WNT_BETA_CATENIN_SIGNALING	Genes up-regulated by activation of WNT signaling through accumulation of beta catenin CTNNB1 [GeneID=1499]	41

Query type

Symbol

Entrez Gene ID

Gene filters

Druggable (TTD)

Druggable (dGene)

Synthetic lethal (DAISY)

Subgroup1 field

Subgroup1 value

Subgroup2 field

Subgroup2 value

Please wait. CTGS are finding target genes. It takes about 1~2 minutes.